姓名：吴利祥

职称：讲师

最高学历学位：博士研究生

电子邮箱：wulixiang1234@126.com

教育经历：

2019.09-2023.12，华中农业大学，水产动物分子营养专业，博士研究生。

2017.09-2019.06，华中农业大学，水产动物分子营养，硕士研究生。

2013.09-2017.06，华中农业大学，水产养殖学，本科。

研究方向：

研究聚焦于高糖代谢对肝脏健康的影响。通过分子生物学手段，解析了高糖通过ROS-AKT1-Beclin1通路激活脂质自噬，从而缓解脂肪肝的发生机制。进一步研究揭示了高糖通过糖基化AKT1抑制糖原自噬，导致肝脏糖原过度蓄积，引发糖原性肝病。此外，研究还发现维生素D₃能够有效缓解高血糖症，抑制炎症，并通过促进糖原自噬，缓解糖原性肝病的发展，深入解析了其分子机制。

主要学术成果：

发表论文10篇，其中第一作者发表论文5篇。参与国家自然科学基金项目3项。

发表的代表性论文：

1. Wu LX, Xu YC, Hogstrand C, Zhao T, Wu K, Xu YH, Liu W, Luo Z*. Lipophagy mediated glucose-induced changes of lipid deposition and metabolism via ROS dependent AKT-Beclin1 activation. J. Nutr. Biochem (营养领域经典top期刊，中科院医学二区）, 2022; 100, 108882.（IF:6.117,Q1）

2. Wu LX, Xu YC, Pantopoulos K, Tan XY, Wei XL, Zheng H, Luo Z. Glycophagy mediated glucose-induced changes of hepatic glycogen metabolism via OGT1-AKT1 FOXO1^Ser238 pathway. J Nutr. Biochem (营养领域经典top期刊，，中科院医学二区）. 2023: 27:109337. （IF:6.117,Q1）

3. Wu LX, Wei CC, Yang SB, Zhao T, Luo Z*, 2019. Effects of fat and fatty acids on the formation of autolysosomes in the livers from yellow catfish Pelteobagrus fulvidraco. Genes, 10, 751.（IF:4.141,，中科院三区）

4. Wu L X, Li QL, Luo Z, SorensenM，Wei XL,Zheng H,Tan XY. Effects of dietary vitamin D3 and carbohydrate levels on growth performance, carbohydrate metabolism, and intestinal health of yellow catfish (Pelteobagrus fulvidraco), Aquaculture. 2024,15,52.（IF:5.5, 中科院一区）

5. Wu LX, Tan XY, Xu YC, Zheng H, Wei XL, Lv WH, Luo Z. SIRT1-NRF2-TFEB axis-mediated hepatic lipophagy alleviates the lipid deposition induced by high glucose in yellow catfish Pelteobagrus fulvidraco. Comp Biochem Physiol B Biochem Mol Biol. 2024:269:110894. . （IF:2.8, 中科院三区）

6. Song CC, Wu LX, Chen GH, Lv WH, Chen SW, Luo Z*, 2020. Six members of SLC30A/ZnTs family related with the control of zinc homeostasis: characterization, mRNA expression and their responses to dietary ZnO nanoparticles in yellow catfish. Aquaculture, 528, 735570.（IF:5.135,Q1）

7. Xu YC, Xu YH, Zhao T, Wu LX, Yang SB, Luo Z*, 2020. Waterborne Cu exposure increased lipid deposition and lipogenesis by affecting Wnt/β-catenin pathway and the β-catenin acetylation levels. Environ. Pollut., 263, 114420.（IF:9.988,Q1）

8. Wei CC, Luo Z*, Hogstrand C, Xu YH, Wu LX, Chen GH, Pan YX, Song YF, 2018. Zinc reduces hepatic lipid deposition and activates lipophagy via Zn²⁺/MTF-1/PPARα and Ca²⁺/CaMKKß/AMPK pathways. FASEB J, 32, 6666-6680.（IF:5.834,Q1）

9. Xu YH, Xu YC, Hogstrand C, Zhao T, Wu LX, Zhuo MQ, Luo Z*, 2020. Waterborne copper exposure up-regulated lipid deposition through the methylation of GRP78 and PGC1α of grass carp Ctenopharyngodon idella. Ecotoxicol. Environ. Saf., 205, 111089.（IF:7.128,Q1）

10. Wu, K., Chen, G.H., Hogstrand, C., Ling, S.C., Wu, L.X., Luo, Z.*, 2021. Methionine-chelated Zn promotes anabolism by integrating mTOR signal and autophagy pathway in juvenile yellow catfish. J. Trace Elem. Med. Biol, 65,126732.（IF:3.995,Q3）